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KMID : 0616620000060020379
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Journal of Soonchunhyang Medical College
2000 Volume.6 No. 2 p.379 ~ p.384
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Lack of Association between Factor ⅩⅢ Val 34 Leu and Ischemic Stroke
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방차옥/Bang, Cha-Ok
최종순/박형국/안무영/홍세용/Choi, Jong-Soon/Park, Hyung-Kook/Ahn, Moo-Yong/Hong, Sae-Yong
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Abstract
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Background and purpose: Although a common G to T point mutation (FXIII Val34Leu) in exon 2 of the alpha-subunit of the FXIII is protective against myocardial infarction and venous thrombosis, there are few reported the association of FXIII Val34Leu and ischemlc stroke. The aim of this study was to investigate the protective role of the FXIII Val34Leu against ischemic stroke and its suggested interaction with the plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism.
Methods: We carried out genotype analyses for FXIII Val34Leu using single-stranded conformation polymorphism and 4G/5G polymorphism in the promoter region of the PAI-1 gene in 53 patients with ischemic stroke and in 82 race-matched control subjects.
Results: Age, hypertension, diabetes, and low-density lipoprotein were significantly higher on ischemic stroke patients. However, genetic distributions of FXIII A subunit and promoter region of PAI-1 were not different on both groups. Even adjusting for age, sex, hypertension, diabetes, and total cholesterol, there were not significantly associated between FXIII Val32Leu or 4G/4G genotype of PAI-1 and ischemic stroke.
Conclusion: FXIII Val34Leu and the 4G/4G genotype of the PAI-1 gene are not significantly associated with an increased or decreased risk of ischemic stroke.
Key Words: FXIII, PAI-1, Genetic polymorphism, Ischemic stroke
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